The “One life, it’s worth an attempt” Pepe meme is a motivational-style edit of Pepe the Frog, often showing him in a contemplative or melancholic pose paired with the caption. The phrase itself reflects a mix of existential reflection and encouragement, suggesting that despite life’s uncertainty, trying is worthwhile. It is believed to have originated from 4Chan. From there, the line was attached to Pepe images and spread through communities in Reddit and X, where it became popular as a bittersweet, reflective meme.